Successful treatment of metastatic colorectal cancer with synchronous <i>BRAF V600E</i> mutation and dMMR with BGB-A317.

Cheng, Yi; Fang, Xue-Feng; Hu, Han-Guang; Wang, Jiang; Sun, Li-Feng; Yuan, Ying

Successful treatment of metastatic colorectal cancer with synchronous BRAF V600E mutation and dMMR with BGB-A317.

Cheng, Yi; Fang, Xue-Feng; Hu, Han-Guang; Wang, Jiang; Sun, Li-Feng; Yuan, Ying.

Afiliação

Cheng Y; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
Fang XF; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
Hu HG; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
Wang J; Department of Colorectal Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
Sun LF; Department of Colorectal Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
Yuan Y; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.

Immunotherapy ; 12(4): 229-234, 2020 03.

Article em En | MEDLINE | ID: mdl-32172642

ABSTRACT

ABSTRACT

Metastatic colorectal cancer with BRAF mutation is a type of highly invasive malignant tumor with poor prognosis and few treatment options. Here, we report a case of a BRAF-mutant and DNA mismatch-repair deficiency colorectal cancer patient with postoperative recurrence as well as abdominal cavity and pelvic metastasis, whose condition was relieved continuously after treatment with a new anti-PD-1 antibody, BGB-A317.

Assuntos

Anticorpos Monoclonais Humanizados/uso terapêutico; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/patologia; Reparo de Erro de Pareamento de DNA/genética; Inibidores de Checkpoint Imunológico/uso terapêutico; Proteínas Proto-Oncogênicas B-raf/genética; Neoplasias Abdominais/tratamento farmacológico; Neoplasias Abdominais/genética; Neoplasias Abdominais/secundário; Adenocarcinoma/tratamento farmacológico; Adenocarcinoma/genética; Adenocarcinoma/secundário; Idoso; Biomarcadores Tumorais/genética; Neoplasias Colorretais/genética; Feminino; Humanos; Imunoterapia; Instabilidade de Microssatélites; Mutação; Neoplasias Pélvicas/tratamento farmacológico; Neoplasias Pélvicas/genética; Neoplasias Pélvicas/secundário; Resultado do Tratamento

Palavras-chave

BRAF mutation; DNA mismatch repair deficiency; PD-1 inhibitors; advanced colorectal cancer; high microsatellite instability; immunotherapy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteínas Proto-Oncogênicas B-raf / Reparo de Erro de Pareamento de DNA / Anticorpos Monoclonais Humanizados / Inibidores de Checkpoint Imunológico Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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