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Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells.
Herrlinger, Eva-Maria; Hau, Mirjam; Redhaber, Desiree Melanie; Greve, Gabriele; Willmann, Dominica; Steimle, Simon; Müller, Michael; Lübbert, Michael; Miething, Christoph Cornelius; Schüle, Roland; Jung, Manfred.
Afiliação
  • Herrlinger EM; Department of Chemistry and Pharmacy, University of Freiburg, Institute of Pharmaceutical Sciences, Albertstrasse 25, 79104, Freiburg, Germany.
  • Hau M; Department of Chemistry and Pharmacy, University of Freiburg, Institute of Pharmaceutical Sciences, Albertstrasse 25, 79104, Freiburg, Germany.
  • Redhaber DM; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, 79104, Freiburg, Germany.
  • Greve G; Division of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Hugstetter Strasse 55, 79106, Freiburg, Germany.
  • Willmann D; Division of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Hugstetter Strasse 55, 79106, Freiburg, Germany.
  • Steimle S; Department of Urology and Center for Clinical Research, University of Freiburg Medical Center, Breisacher Strasse 66, 79106, Freiburg, Germany.
  • Müller M; Department of Chemistry and Pharmacy, University of Freiburg, Institute of Pharmaceutical Sciences, Albertstrasse 25, 79104, Freiburg, Germany.
  • Lübbert M; Department of Chemistry and Pharmacy, University of Freiburg, Institute of Pharmaceutical Sciences, Albertstrasse 25, 79104, Freiburg, Germany.
  • Miething CC; Division of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Hugstetter Strasse 55, 79106, Freiburg, Germany.
  • Schüle R; German Cancer Consortium (DKTK), Freiburg, Germany.
  • Jung M; German Cancer Research Center (DKFZ).
Chembiochem ; 21(16): 2329-2347, 2020 08 17.
Article em En | MEDLINE | ID: mdl-32227662
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nitrorredutases / Pró-Fármacos / Leucemia Mieloide Aguda / Inibidores Enzimáticos / Histona Desmetilases / Liberação Controlada de Fármacos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nitrorredutases / Pró-Fármacos / Leucemia Mieloide Aguda / Inibidores Enzimáticos / Histona Desmetilases / Liberação Controlada de Fármacos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article