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A novel potent metal-binding NDM-1 inhibitor was identified by fragment virtual, SPR and NMR screening.
Guo, Huifang; Cheng, Kai; Gao, Yan; Bai, Weiqi; Wu, Cai; He, Wei; Li, Conggang; Li, Zhuorong.
Afiliação
  • Guo H; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
  • Cheng K; Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.
  • Gao Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
  • Bai W; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
  • Wu C; School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
  • He W; School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
  • Li C; Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China. Electronic address:
  • Li Z; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China. Electronic address: lizhuorong@imb.pumc.edu.cn.
Bioorg Med Chem ; 28(9): 115437, 2020 05 01.
Article em En | MEDLINE | ID: mdl-32229085
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Zinco / Beta-Lactamases / Inibidores Enzimáticos / Complexos de Coordenação / Klebsiella pneumoniae / Antibacterianos Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Zinco / Beta-Lactamases / Inibidores Enzimáticos / Complexos de Coordenação / Klebsiella pneumoniae / Antibacterianos Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article