Acute Effects of Glucagon on Reproductive Hormone Secretion in Healthy Men.
J Clin Endocrinol Metab
; 105(6)2020 06 01.
Article
em En
| MEDLINE
| ID: mdl-32232363
ABSTRACT
CONTEXT Glucagon increases energy expenditure; consequently, glucagon receptor agonists are in development for the treatment of obesity. Obesity negatively affects the reproductive axis, and hypogonadism itself can exacerbate weight gain. Therefore, knowledge of the effects of glucagon receptor agonism on reproductive hormones is important for developing therapeutics for obesity; but reports in the literature about the effects of glucagon receptor agonism on the reproductive axis are conflicting. OBJECTIVE:
The objective of this work is to investigate the effect of glucagon administration on reproductive hormone secretion in healthy young men.DESIGN:
A single-blinded, randomized, placebo-controlled crossover study was conducted.SETTING:
The setting of this study was the Clinical Research Facility, Imperial College Healthcare NHS Trust.PARTICIPANTS:
Eighteen healthy eugonadal men (meanâ ±â SEM age 25.1â ±â 1.0 years; body mass index 22.5â ±â 0.4 kg/m2; testosterone 21.2â ±â 1.2 nmol/L) participated in this study. INTERVENTION An 8-hour intravenous infusion of 2 pmol/kg/min glucagon or rate-matched vehicle infusion was administered. MAIN OUTCOMEMEASURES:
Luteinizing hormone (LH) pulsatility; LH, follicle-stimulating hormone (FSH), and testosterone levels were measured.RESULTS:
Although glucagon administration induced metabolic effects (insulin area under the curve vehicle 1065â ±â 292 min.µU/mL vs glucagon 2098â ±â 358 min.µU/mL, Pâ <â .001), it did not affect LH pulsatility (number of LH pulses/500 min vehicle 4.7â ±â 0.4, glucagon 4.2â ±â 0.4, Pâ =â .22). Additionally, there were no significant differences in circulating LH, FSH, or testosterone levels during glucagon administration compared with vehicle administration.CONCLUSIONS:
Acute administration of a metabolically active dose of glucagon does not alter reproductive hormone secretion in healthy men. These data are important for the continued development of glucagon-based treatments for obesity.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reprodução
/
Testosterona
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Fármacos Gastrointestinais
/
Glucagon
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Hormônio Luteinizante
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Biomarcadores
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Hormônio Foliculoestimulante
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Adult
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Humans
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article