KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer.

Alam, Hunain; Tang, Ming; Maitituoheti, Mayinuer; Dhar, Shilpa S; Kumar, Manish; Han, Chae Young; Ambati, Chandrashekar R; Amin, Samir B; Gu, Bingnan; Chen, Tsai-Yu; Lin, Yu-Hsi; Chen, Jichao; Muller, Florian L; Putluri, Nagireddy; Flores, Elsa R; DeMayo, Francesco J; Baseler, Laura; Rai, Kunal; Lee, Min Gyu

Alam, Hunain; Tang, Ming; Maitituoheti, Mayinuer; Dhar, Shilpa S; Kumar, Manish; Han, Chae Young; Ambati, Chandrashekar R; Amin, Samir B; Gu, Bingnan; Chen, Tsai-Yu; Lin, Yu-Hsi; Chen, Jichao; Muller, Florian L; Putluri, Nagireddy; Flores, Elsa R; DeMayo, Francesco J; Baseler, Laura; Rai, Kunal; Lee, Min Gyu.

Afiliação

Alam H; Department of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Tang M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1901 East Road, Houston, TX 77054, USA.
Maitituoheti M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1901 East Road, Houston, TX 77054, USA.
Dhar SS; Department of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Kumar M; Department of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Han CY; Department of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Ambati CR; Advanced Technology Core and Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Amin SB; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1901 East Road, Houston, TX 77054, USA.
Gu B; Department of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Chen TY; Department of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Lin YH; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 1881 East Road, Houston, TX 77054, USA.
Chen J; Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Muller FL; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 1881 East Road, Houston, TX 77054, USA.
Putluri N; Advanced Technology Core and Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Flores ER; Department of Molecular Oncology and Cancer Biology and Evolution Program, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.
DeMayo FJ; Reproductive and Developmental Biology Laboratory, The National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.
Baseler L; Department of Veterinary Medicine & Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Rai K; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1901 East Road, Houston, TX 77054, USA. Electronic address: KRai@mdanderson.org.
Lee MG; Department of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address: mglee@mdanderson.org.

Cancer Cell ; 37(4): 599-617.e7, 2020 04 13.

Article em En | MEDLINE | ID: mdl-32243837

Assuntos

Adenocarcinoma de Pulmão/patologia; Proteínas de Ligação a DNA/antagonistas & inibidores; Desoxiglucose/farmacologia; Elementos Facilitadores Genéticos; Regulação Neoplásica da Expressão Gênica; Glicólise; Histona-Lisina N-Metiltransferase/fisiologia; Proteína de Leucina Linfoide-Mieloide/fisiologia; Proteínas de Neoplasias/antagonistas & inibidores; Adenocarcinoma de Pulmão/tratamento farmacológico; Adenocarcinoma de Pulmão/metabolismo; Animais; Antimetabólitos/farmacologia; Apoptose; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Proliferação de Células; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Histonas/genética; Histonas/metabolismo; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patologia; Camundongos; Camundongos Knockout; Camundongos Nus; Mutação; Proteínas de Neoplasias/genética; Proteínas de Neoplasias/metabolismo; Proteínas Circadianas Period/genética; Proteínas Circadianas Period/metabolismo; Prognóstico; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

KMT2D; epigenetic modifier; glycolysis; histone methylation; histone methyltransferase; inhibitor; lung cancer; metabolism; super-enhancer; tumor suppressor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Histona-Lisina N-Metiltransferase / Elementos Facilitadores Genéticos / Desoxiglucose / Proteínas de Ligação a DNA / Proteína de Leucina Linfoide-Mieloide / Adenocarcinoma de Pulmão / Glicólise / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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