Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression.

Savadlou, Aisouda; Arnatkeviciute, Aurina; Tiego, Jeggan; Hawi, Ziarih; Bellgrove, Mark A; Fornito, Alex; Bousman, Chad

Savadlou, Aisouda; Arnatkeviciute, Aurina; Tiego, Jeggan; Hawi, Ziarih; Bellgrove, Mark A; Fornito, Alex; Bousman, Chad.

Afiliação

Savadlou A; Department of Neuroscience, University of Calgary, Calgary, AB, Canada.
Arnatkeviciute A; Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Australia.
Tiego J; Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Australia.
Hawi Z; Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Australia.
Bellgrove MA; Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Australia.
Fornito A; Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Australia.
Bousman C; Departments of Medical Genetics, Psychiatry, and Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Alberta Children'

Psychiatry Res ; 288: 112984, 2020 06.

Article em En | MEDLINE | ID: mdl-32315880

Assuntos

Ansiedade/diagnóstico por imagem; Citocromo P-450 CYP2C19/metabolismo; Depressão/diagnóstico por imagem; Genótipo; Hipocampo/diagnóstico por imagem; Adulto; Animais; Ansiedade/enzimologia; Ansiedade/genética; Estudos Transversais; Citocromo P-450 CYP2C19/genética; Depressão/enzimologia; Depressão/genética; Ativação Enzimática/fisiologia; Feminino; Hipocampo/enzimologia; Humanos; Masculino; Tamanho do Órgão/fisiologia

Palavras-chave

CYP2C19; Hippocampus; Metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ansiedade / Depressão / Citocromo P-450 CYP2C19 / Genótipo / Hipocampo Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Animals / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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