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Recent and Emerging Therapies for Cutaneous Squamous Cell Carcinomas of the Head and Neck.
Varra, Vamsi; Smile, Timothy D; Geiger, Jessica L; Koyfman, Shlomo A.
Afiliação
  • Varra V; Case Western Reserve University School of Medicine, Cleveland, OH, USA. vamsivarra@yahoo.com.
  • Smile TD; Cleveland Clinic Foundation, Cleveland, OH, USA.
  • Geiger JL; Cleveland Clinic Foundation, Cleveland, OH, USA.
  • Koyfman SA; Cleveland Clinic Foundation, Cleveland, OH, USA.
Curr Treat Options Oncol ; 21(5): 37, 2020 04 23.
Article em En | MEDLINE | ID: mdl-32328817
ABSTRACT
OPINION STATEMENT Cutaneous squamous cell carcinoma (cSCC) of the head and neck is typically managed with Mohs Micrographic Surgery (MMS) for cosmetic reasons. MMS also improves oncologic outcomes for high-risk tumors. Patients with certain high-risk subsets of the disease also benefit from adjuvant radiation therapy. The PD-1 inhibitor, cemiplimab, was recently approved for treatment of locally advanced and metastatic cSCC unamenable to curative surgery or radiation therapy after the drug demonstrated encouraging, durable response rates. Cemiplimab and other systemic immunotherapies are now being evaluated in clinical trials in the neoadjuvant and adjuvant settings as well. Localized immunotherapies are also being studied, including oncolytic viruses such as talimogene laherparepvec, a modified herpes simplex virus previously approved for the treatment of advanced cutaneous melanoma. Most importantly, multidisciplinary care is crucial in optimizing outcomes for patients with high-risk cSCC of the head and neck.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma de Células Escamosas de Cabeça e Pescoço Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma de Células Escamosas de Cabeça e Pescoço Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article