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Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity.
Singh, Kawaljit; Kaur, Gurminder; Shanika, Petrus Siningu; Dziwornu, Godwin Akpeko; Okombo, John; Chibale, Kelly.
Afiliação
  • Singh K; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa; South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebos
  • Kaur G; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa.
  • Shanika PS; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
  • Dziwornu GA; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
  • Okombo J; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
  • Chibale K; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa; South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebos
Bioorg Med Chem ; 28(13): 115530, 2020 07 01.
Article em En | MEDLINE | ID: mdl-32362386
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Ácido Fusídico / Antibacterianos / Mycobacterium Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Ácido Fusídico / Antibacterianos / Mycobacterium Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article