Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular <sup>18</sup>F-FDG Uptake in Atherosclerotic Mice.

Ståhle, Mia; Silvola, Johanna M U; Hellberg, Sanna; de Vries, Margreet; Quax, Paul H A; Kroon, Jeffrey; Rinne, Petteri; de Jong, Alwin; Liljenbäck, Heidi; Savisto, Nina; Wickman, Anna; Stroes, Erik S G; Ylä-Herttuala, Seppo; Saukko, Pekka; Abrahamsson, Tommy; Pettersson, Knut; Knuuti, Juhani; Roivainen, Anne; Saraste, Antti

Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular ¹⁸F-FDG Uptake in Atherosclerotic Mice.

Ståhle, Mia; Silvola, Johanna M U; Hellberg, Sanna; de Vries, Margreet; Quax, Paul H A; Kroon, Jeffrey; Rinne, Petteri; de Jong, Alwin; Liljenbäck, Heidi; Savisto, Nina; Wickman, Anna; Stroes, Erik S G; Ylä-Herttuala, Seppo; Saukko, Pekka; Abrahamsson, Tommy; Pettersson, Knut; Knuuti, Juhani; Roivainen, Anne; Saraste, Antti.

Afiliação

Ståhle M; Turku PET Centre, University of Turku, Turku, Finland.
Silvola JMU; Turku PET Centre, University of Turku, Turku, Finland.
Hellberg S; Turku PET Centre, University of Turku, Turku, Finland.
de Vries M; Einthoven Laboratory for Experimental Vascular Medicine, Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Quax PHA; Einthoven Laboratory for Experimental Vascular Medicine, Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Kroon J; Department of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Rinne P; Research Center for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
de Jong A; Turku Center for Disease Modeling, University of Turku, Turku, Finland.
Liljenbäck H; Einthoven Laboratory for Experimental Vascular Medicine, Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Savisto N; Turku PET Centre, University of Turku, Turku, Finland.
Wickman A; Turku Center for Disease Modeling, University of Turku, Turku, Finland.
Stroes ESG; Turku PET Centre, University of Turku, Turku, Finland.
Ylä-Herttuala S; i3tex AB, Gothenburg, Sweden.
Saukko P; Department of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Abrahamsson T; Department of Vascular Medicine, Academic Medical Center, Amsterdam University Medical Center (UMC), Amsterdam, the Netherlands.
Pettersson K; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Knuuti J; Department of Pathology and Forensic Medicine, University of Turku, Turku, Finland.
Roivainen A; Athera Biotechnologies AB, Stockholm, Sweden.
Saraste A; Athera Biotechnologies AB, Stockholm, Sweden.

JACC Basic Transl Sci ; 5(4): 360-373, 2020 Apr.

Article em En | MEDLINE | ID: mdl-32368695

ABSTRACT

ABSTRACT

This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.

Palavras-chave

18F-FDG, 18F-fluorodeoxyglucose; 18F-fluorodeoxyglucose positron emission tomography; ANOVA, analysis of variance; ApoB, apolipoprotein-B; CFR, coronary flow reserve; HAEC, human aortic endothelial cell; ICAM, intracellular adhesion molecule; IL, interleukin; Ig, immunoglobulin; LDLR, low-density lipoprotein receptor; Lp(a), lipoprotein(a); NO, nitric oxide; OxLDL, oxidized low-density lipoprotein cholesterol; OxPLs, oxidized phospholipids; PC, phosphorylcholine; PC-mAb, human PC antibody; VCAM, vascular cell adhesion molecule; atherosclerosis; coronary flow reserve; inflammation; phosphorylcholine

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article