Specificity in the biosynthesis of the universal tRNA nucleoside N6-threonylcarbamoyl adenosine (t6A)-TsaD is the gatekeeper.

Swinehart, William; Deutsch, Christopher; Sarachan, Kathryn L; Luthra, Amit; Bacusmo, Jo Marie; de Crécy-Lagard, Valérie; Swairjo, Manal A; Agris, Paul F; Iwata-Reuyl, Dirk

Specificity in the biosynthesis of the universal tRNA nucleoside N⁶-threonylcarbamoyl adenosine (t⁶A)-TsaD is the gatekeeper.

Swinehart, William; Deutsch, Christopher; Sarachan, Kathryn L; Luthra, Amit; Bacusmo, Jo Marie; de Crécy-Lagard, Valérie; Swairjo, Manal A; Agris, Paul F; Iwata-Reuyl, Dirk.

Afiliação

Swinehart W; Department of Chemistry, Portland State University, Portland, Oregon 97201, USA.
Deutsch C; Department of Chemistry, Portland State University, Portland, Oregon 97201, USA.
Sarachan KL; The RNA Institute, State University of New York, Albany, New York 12222, USA.
Luthra A; Department of Chemistry and Biochemistry, and The Viral Information Institute, San Diego State University, San Diego, California 92182, USA.
Bacusmo JM; Department of Microbiology and Cell Science, University of Florida, Gainsville, Florida 32611, USA.
de Crécy-Lagard V; Department of Microbiology and Cell Science, University of Florida, Gainsville, Florida 32611, USA.
Swairjo MA; Department of Chemistry and Biochemistry, and The Viral Information Institute, San Diego State University, San Diego, California 92182, USA.
Agris PF; The RNA Institute, State University of New York, Albany, New York 12222, USA.
Iwata-Reuyl D; Department of Chemistry, Portland State University, Portland, Oregon 97201, USA.

RNA ; 26(9): 1094-1103, 2020 09.

Article em En | MEDLINE | ID: mdl-32385138

Assuntos

Adenosina/análogos & derivados; Vias Biossintéticas/genética; Nucleosídeos/genética; RNA de Transferência/genética; Adenosina/genética; Monofosfato de Adenosina/genética; Trifosfato de Adenosina/genética; Aminoácidos/genética; Domínio Catalítico/genética; Escherichia coli/genética; Conformação Proteica; Especificidade por Substrato/genética; Thermotoga maritima/genética; Treonina/genética

Palavras-chave

N6-hydroxynorvalylcarbabamoyl adenosine; N6-threonylcarbamoyl adenosine; RNA modification; kinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA de Transferência / Adenosina / Vias Biossintéticas / Nucleosídeos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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