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Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.
Psaila, Bethan; Wang, Guanlin; Rodriguez-Meira, Alba; Li, Rong; Heuston, Elisabeth F; Murphy, Lauren; Yee, Daniel; Hitchcock, Ian S; Sousos, Nikolaos; O'Sullivan, Jennifer; Anderson, Stacie; Senis, Yotis A; Weinberg, Olga K; Calicchio, Monica L; Iskander, Deena; Royston, Daniel; Milojkovic, Dragana; Roberts, Irene; Bodine, David M; Thongjuea, Supat; Mead, Adam J.
Afiliação
  • Psaila B; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, University of
  • Wang G; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, University of
  • Rodriguez-Meira A; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, University of
  • Li R; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, University of
  • Heuston EF; Hematopoiesis Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-4442, USA.
  • Murphy L; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, University of
  • Yee D; York Biomedical Research Institute and Department of Biology, University of York, Heslington, York YO10 5DD, UK.
  • Hitchcock IS; York Biomedical Research Institute and Department of Biology, University of York, Heslington, York YO10 5DD, UK.
  • Sousos N; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, University of
  • O'Sullivan J; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, University of
  • Anderson S; NHGRI Flow Cytometry Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-4442, USA.
  • Senis YA; Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-S 1255, Etablissement Français du Sang Grand Est, Strasbourg 67065, France.
  • Weinberg OK; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.
  • Calicchio ML; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.
  • Iskander D; Centre for Haematology, Hammersmith Hospital, Imperial College of Medicine, London W12 OHS, UK.
  • Royston D; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
  • Milojkovic D; Centre for Haematology, Hammersmith Hospital, Imperial College of Medicine, London W12 OHS, UK.
  • Roberts I; MRC Molecular Haematology Unit, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, University of Oxford, Oxford OX4 2PG, UK; Department of Paediatrics, University of Oxford, Oxford OX3 9DU, UK.
  • Bodine DM; Hematopoiesis Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-4442, USA.
  • Thongjuea S; NIHR Biomedical Research Centre, University of Oxford, Oxford OX4 2PG, UK; MRC WIMM Centre for Computational Biology, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK. Electronic address: supat.thongjuea@imm.ox.ac.uk.
  • Mead AJ; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, University of
Mol Cell ; 78(3): 477-492.e8, 2020 05 07.
Article em En | MEDLINE | ID: mdl-32386542
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Megacariócitos / Mielofibrose Primária / Hematopoese Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Megacariócitos / Mielofibrose Primária / Hematopoese Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article