Therapeutic targeting of miRNA-216b in cancer.
Cancer Lett
; 484: 16-28, 2020 08 01.
Article
em En
| MEDLINE
| ID: mdl-32387443
ABSTRACT
MicroRNAs (miRNAs/or miR) are a type of small, non-coding RNAs that regulate gene expression by binding to 3'-UTRs of the target genes. miRNAs can serve as oncogenes or tumor suppressors, and have prognostic and therapeutic values that may be directly applicable in the clinic. miR-216b is located on chromosome 2p16.1. Accumulating evidence suggests that it acts as a tumor suppressor and its downregulation may play a significant role in cancer biology through the dysregulation of various oncogenes and signaling pathways related to cancer cell proliferation, cell cycle progression, migration, invasion, apoptosis, and chemoresistance. In this review, we discuss the aberrant expression of miR-216b in cancer and its role in tumor pathogenesis, which will offer novel insights into its clinical applications.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
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Regulação Neoplásica da Expressão Gênica
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Genes Supressores de Tumor
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MicroRNAs
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Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article