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Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer's disease risk.
Murcia, Josue D Gonzalez; Weinert, Allen; Freitas, Claudia M Tellez; Arens, Daniel K; Ferrel, Meganne N; Grose, Julianne H; Ridge, Perry G; Wilson, Eric; Kauwe, John S K; Weber, K Scott.
Afiliação
  • Murcia JDG; Brigham Young University, Department of Biology, 4102 Life Sciences Building, Provo, Utah, 84602, USA.
  • Weinert A; Brigham Young University, Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, Provo, Utah, 84602, USA.
  • Freitas CMT; Brigham Young University, Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, Provo, Utah, 84602, USA.
  • Arens DK; Roseman University of Health Science College of Dental Medicine 10894 S, River Front Parkway, South Jordan, UT, 84095, USA.
  • Ferrel MN; Brigham Young University, Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, Provo, Utah, 84602, USA.
  • Grose JH; Brigham Young University, Department of Biology, 4102 Life Sciences Building, Provo, Utah, 84602, USA.
  • Ridge PG; Brigham Young University, Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, Provo, Utah, 84602, USA.
  • Wilson E; Brigham Young University, Department of Biology, 4102 Life Sciences Building, Provo, Utah, 84602, USA.
  • Kauwe JSK; Brigham Young University, Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, Provo, Utah, 84602, USA.
  • Weber KS; Brigham Young University, Department of Biology, 4102 Life Sciences Building, Provo, Utah, 84602, USA. kauwe@byu.edu.
Sci Rep ; 10(1): 8019, 2020 05 15.
Article em En | MEDLINE | ID: mdl-32415244
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quimiocina CCL2 / Receptores de Quimiocinas / Proteínas Mutantes / Doença de Alzheimer / Inflamação Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quimiocina CCL2 / Receptores de Quimiocinas / Proteínas Mutantes / Doença de Alzheimer / Inflamação Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article