Histopathology of castration-resistant prostate cancer confirms changes in bone metastasis during radium-223 treatment: A case report.
Urol Case Rep
; 32: 101230, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-32420038
ABSTRACT
Radium-223 is used for treating castration-resistant prostate cancer with bone metastases. Here, we report the case of a 76-year-old man diagnosed with castration-resistant prostate cancer with bone metastases who was started on radium-223. Although the patient ultimately died from causes unrelated to the treatment before starting the third treatment course, we observed that radium-223 was more effective in areas closer to the bone cortex than in deeper tumor regions. Through histopathological analysis, we provide important mechanistic insights on the therapeutic effect of radium-223 in human prostate cancer bone metastases.
ALP, alkaline phosphatase; Bone metastasis; CAB, combined androgen blockade; CRPC, castration-resistant prostate cancer; Castration-resistant prostate cancer; Histopathology; OS, overall survival; PSA, prostate-specific antigen; RANKL, receptor activator of nuclear factor-κB ligand; Ra-223, radium-223; Radium-223; SRE, skeletal related event
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MEDLINE
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2020
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Article