Lactulose and Melibiose Inhibit &#945;-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.

Chen, Chiung Mei; Lin, Chih-Hsin; Wu, Yih-Ru; Yen, Chien-Yu; Huang, Yu-Ting; Lin, Jia-Lan; Lin, Chung-Yin; Chen, Wan-Ling; Chao, Chih-Ying; Lee-Chen, Guey-Jen; Su, Ming-Tsan; Chang, Kuo-Hsuan

Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.

Chen, Chiung Mei; Lin, Chih-Hsin; Wu, Yih-Ru; Yen, Chien-Yu; Huang, Yu-Ting; Lin, Jia-Lan; Lin, Chung-Yin; Chen, Wan-Ling; Chao, Chih-Ying; Lee-Chen, Guey-Jen; Su, Ming-Tsan; Chang, Kuo-Hsuan.

Afiliação

Chen CM; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.
Lin CH; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.
Wu YR; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.
Yen CY; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Huang YT; Taipei First Girls High School, Taipei 10045, Taiwan.
Lin JL; Taipei First Girls High School, Taipei 10045, Taiwan.
Lin CY; Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Taoyuan 33302, Taiwan.
Chen WL; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.
Chao CY; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.
Lee-Chen GJ; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Su MT; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Chang KH; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.

Cells ; 9(5)2020 05 16.

Article em En | MEDLINE | ID: mdl-32429337

Assuntos

Autofagia/efeitos dos fármacos; Lactulose/farmacologia; Melibiose/farmacologia; Neurônios/metabolismo; Agregados Proteicos; Regulação para Cima; alfa-Sinucleína/metabolismo; Sequência de Aminoácidos; Antioxidantes/farmacologia; Benzotiazóis/metabolismo; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Neurônios Dopaminérgicos/efeitos dos fármacos; Neurônios Dopaminérgicos/metabolismo; Fluorescência; Proteínas de Fluorescência Verde/metabolismo; Humanos; Lactulose/química; Melibiose/química; Crescimento Neuronal/efeitos dos fármacos; Neurônios/efeitos dos fármacos; Fármacos Neuroprotetores/farmacologia; Estresse Oxidativo/efeitos dos fármacos; Agregados Proteicos/efeitos dos fármacos; Trealose/química; Trealose/farmacologia; Regulação para Cima/efeitos dos fármacos; alfa-Sinucleína/química

Palavras-chave

Parkinson's disease; autophagy inducer; lactulose; melibiose; α-synuclein aggregation inhibition

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Regulação para Cima / Alfa-Sinucleína / Agregados Proteicos / Lactulose / Melibiose / Neurônios Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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