Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA.

Kong, Muwen; Cutts, Erin E; Pan, Dongqing; Beuron, Fabienne; Kaliyappan, Thangavelu; Xue, Chaoyou; Morris, Edward P; Musacchio, Andrea; Vannini, Alessandro; Greene, Eric C

Kong, Muwen; Cutts, Erin E; Pan, Dongqing; Beuron, Fabienne; Kaliyappan, Thangavelu; Xue, Chaoyou; Morris, Edward P; Musacchio, Andrea; Vannini, Alessandro; Greene, Eric C.

Afiliação

Kong M; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Cutts EE; Division of Structural Biology, The Institute of Cancer Research, London SW7 3RP, UK.
Pan D; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Beuron F; Division of Structural Biology, The Institute of Cancer Research, London SW7 3RP, UK.
Kaliyappan T; Division of Structural Biology, The Institute of Cancer Research, London SW7 3RP, UK.
Xue C; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Morris EP; Division of Structural Biology, The Institute of Cancer Research, London SW7 3RP, UK.
Musacchio A; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Vannini A; Division of Structural Biology, The Institute of Cancer Research, London SW7 3RP, UK; Fondazione Human Technopole, Structural Biology Research Centre, 20157 Milan, Italy. Electronic address: alessandro.vannini@icr.ac.uk.
Greene EC; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: ecg2108@cumc.columbia.edu.

Mol Cell ; 79(1): 99-114.e9, 2020 07 02.

Article em En | MEDLINE | ID: mdl-32445620

Assuntos

Adenosina Trifosfatases/química; Adenosina Trifosfatases/metabolismo; Trifosfato de Adenosina/metabolismo; Proteínas de Ligação a DNA/química; Proteínas de Ligação a DNA/metabolismo; DNA/química; DNA/metabolismo; Complexos Multiproteicos/química; Complexos Multiproteicos/metabolismo; Nucleossomos/metabolismo; Adenosina Trifosfatases/genética; Proteínas de Ligação a DNA/genética; Humanos; Modelos Moleculares; Complexos Multiproteicos/genética; Ligação Proteica; Conformação Proteica; Imagem Individual de Molécula/métodos

Palavras-chave

DNA curtain; SMC complexes; chromosome organization; condensin; crosslinking mass spectroscopy; electron microscopy; loop extrusion; single molecule

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA / Nucleossomos / Trifosfato de Adenosina / Adenosina Trifosfatases / Complexos Multiproteicos / Proteínas de Ligação a DNA Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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