Body Mass Index Predicts Decline in Executive Function in Bipolar Disorder: Preliminary Data of a 12-Month Follow-up Study.
Neuropsychobiology
; 80(1): 1-11, 2021.
Article
em En
| MEDLINE
| ID: mdl-32454501
ABSTRACT
INTRODUCTION:
Obesity and associated risk factors have been linked to cognitive decline before.OBJECTIVES:
In the present study, we evaluated potential cumulative negative effects of overweight and obesity on cognitive performance in euthymic patients with bipolar disorder (BD) in a longitudinal design.METHODS:
Neurocognitive measures (California Verbal Learning Test, Trail Making Test [TMT] A/B, Digit-Symbol-Test, Digit-Span, d2 Test), anthropometrics (e.g., body mass index [BMI]), and clinical ratings (Hamilton Depression Scale, Young Mania Rating Scale) were collected over a 12-month observation period. Follow-up data of 38 patients with BD (mean age 40 years; 15 males, 23 females) were available.RESULTS:
High baseline BMI predicted a decrease in the patient's performance in the Digit-Span backwards task measuring working memory performance. In contrast, cognitive performance was not predicted by increases in BMI at follow-up. Normal weight bipolar patients (n = 19) improved their performance on the TMT B, measuring cognitive flexibility and executive functioning, within 1 year, while overweight bipolar patients (n = 19) showed no change in this task.CONCLUSIONS:
The results suggest that overweight can predict cognitive performance changes over 12 months.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Transtorno Bipolar
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Índice de Massa Corporal
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Sobrepeso
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Função Executiva
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Disfunção Cognitiva
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article