Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin.
Antimicrob Agents Chemother
; 64(8)2020 07 22.
Article
em En
| MEDLINE
| ID: mdl-32457108
ABSTRACT
Novel antiparasitic activity was observed for the antifungal occidiofungin. It efficaciously and irreversibly inhibited the zoonotic enteric parasite Cryptosporidium parvumin vitro with limited cytotoxicity (50% effective concentration [EC50] = 120 nM versus 50% cytotoxic concentration [TC50] = 988 nM), and its application disrupted the parasite morphology. This study expands the spectrum of activity of a glycolipopeptide named occidiofungin. Occidiofungin has poor gastrointestinal tract absorption properties, supporting future investigations into its potential activities on other enteric parasites.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cryptosporidium parvum
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Criptosporidiose
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Cryptosporidium
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article