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Remote nongenetic optical modulation of neuronal activity using fuzzy graphene.
Rastogi, Sahil K; Garg, Raghav; Scopelliti, Matteo Giuseppe; Pinto, Bernardo I; Hartung, Jane E; Kim, Seokhyoung; Murphey, Corban G E; Johnson, Nicholas; San Roman, Daniel; Bezanilla, Francisco; Cahoon, James F; Gold, Michael S; Chamanzar, Maysam; Cohen-Karni, Tzahi.
Afiliação
  • Rastogi SK; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213.
  • Garg R; Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213.
  • Scopelliti MG; Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213.
  • Pinto BI; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637.
  • Hartung JE; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213.
  • Kim S; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
  • Murphey CGE; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
  • Johnson N; Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213.
  • San Roman D; Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213.
  • Bezanilla F; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637.
  • Cahoon JF; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
  • Gold MS; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213.
  • Chamanzar M; Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213.
  • Cohen-Karni T; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213; tzahi@andrew.cmu.edu.
Proc Natl Acad Sci U S A ; 117(24): 13339-13349, 2020 06 16.
Article em En | MEDLINE | ID: mdl-32482882
ABSTRACT
The ability to modulate cellular electrophysiology is fundamental to the investigation of development, function, and disease. Currently, there is a need for remote, nongenetic, light-induced control of cellular activity in two-dimensional (2D) and three-dimensional (3D) platforms. Here, we report a breakthrough hybrid nanomaterial for remote, nongenetic, photothermal stimulation of 2D and 3D neural cellular systems. We combine one-dimensional (1D) nanowires (NWs) and 2D graphene flakes grown out-of-plane for highly controlled photothermal stimulation at subcellular precision without the need for genetic modification, with laser energies lower than a hundred nanojoules, one to two orders of magnitude lower than Au-, C-, and Si-based nanomaterials. Photothermal stimulation using NW-templated 3D fuzzy graphene (NT-3DFG) is flexible due to its broadband absorption and does not generate cellular stress. Therefore, it serves as a powerful toolset for studies of cell signaling within and between tissues and can enable therapeutic interventions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanoestruturas / Grafite / Neurônios Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanoestruturas / Grafite / Neurônios Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article