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Design, synthesis and evaluation of pyrazolopyrimidinone derivatives as novel PDE9A inhibitors for treatment of Alzheimer's disease.
Zhang, Pei; Jiang, Mei-Yan; Le, Mei-Ling; Zhang, Bei; Zhou, Qian; Wu, Yinuo; Zhang, Chen; Luo, Hai-Bin.
Afiliação
  • Zhang P; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
  • Jiang MY; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
  • Le ML; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
  • Zhang B; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
  • Zhou Q; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
  • Wu Y; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China. Electronic address: wyinuo3@mail.sysu.edu.cn.
  • Zhang C; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China. Electronic address: zhangch328@mail.sysu.edu.cn.
  • Luo HB; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
Bioorg Med Chem Lett ; 30(14): 127254, 2020 07 15.
Article em En | MEDLINE | ID: mdl-32527553
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinonas / 3',5'-AMP Cíclico Fosfodiesterases / Fármacos Neuroprotetores / Inibidores Enzimáticos / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinonas / 3',5'-AMP Cíclico Fosfodiesterases / Fármacos Neuroprotetores / Inibidores Enzimáticos / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article