Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130.

Mossner, Sofie; Kuchner, Marcus; Fazel Modares, Nastaran; Knebel, Birgit; Al-Hasani, Hadi; Floss, Doreen M; Scheller, Jürgen

Mossner, Sofie; Kuchner, Marcus; Fazel Modares, Nastaran; Knebel, Birgit; Al-Hasani, Hadi; Floss, Doreen M; Scheller, Jürgen.

Afiliação

Mossner S; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Kuchner M; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Fazel Modares N; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Knebel B; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Al-Hasani H; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Floss DM; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Scheller J; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany jscheller@uni-duesseldorf.de.

J Biol Chem ; 295(35): 12378-12397, 2020 08 28.

Article em En | MEDLINE | ID: mdl-32611765

Assuntos

Receptor gp130 de Citocina/metabolismo; Subunidade beta de Receptor de Interleucina-10/metabolismo; Interleucinas/metabolismo; Multimerização Proteica; Animais; Células CHO; Cricetulus; Receptor gp130 de Citocina/genética; Células HEK293; Humanos; Subunidade beta de Receptor de Interleucina-10/genética; Interleucinas/genética; Camundongos; Domínios Proteicos; Receptores de Interleucina/genética; Receptores de Interleucina/metabolismo; Interleucina 22

Palavras-chave

IL-10 family; IL-10R2; IL-22Rα1; cytokine; cytokine interleukin IL-22; gp130; green fluorescent protein; nanobody; receptor; signal transduction; synthetic biology; synthetic receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interleucinas / Receptor gp130 de Citocina / Subunidade beta de Receptor de Interleucina-10 / Multimerização Proteica Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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