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Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis.
Esteras, Raquel; Fox, Jonathan G; Geddes, Colin C; Mackinnon, Bruce; Ortiz, Alberto; Moreno, Juan Antonio.
Afiliação
  • Esteras R; Renal Laboratory, Health Research Institute-Fundación Jimenez Diaz (IIS-FJD), Autónoma University of Madrid (UAM), 28040 Madrid, Spain.
  • Fox JG; Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow G51 4TF, UK.
  • Geddes CC; Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow G51 4TF, UK.
  • Mackinnon B; Department of Nephrology and Transplantation, John Hunter Hospital, Newcastle, NSW 2310, Australia.
  • Ortiz A; Renal Laboratory, Health Research Institute-Fundación Jimenez Diaz (IIS-FJD), Autónoma University of Madrid (UAM), 28040 Madrid, Spain.
  • Moreno JA; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14041 Cordoba, Spain.
J Clin Med ; 9(7)2020 Jul 07.
Article em En | MEDLINE | ID: mdl-32645825
Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury. Although haematuria is a risk factor for the development of renal disease, no previous study has analyzed the significance of haematuria in ATIN. Retrospective, observational analysis of 110 patients with biopsy-proven ATIN was conducted. Results: Haematuria was present in 66 (60%) ATIN patients. A higher percentage of ATIN patients with haematuria had proteinuria than patients without haematuria (89.4% vs. 59.1%, p = 0.001) with significantly higher levels of proteinuria (median (interquartile range) protein:creatinine ratio 902.70 (513-1492) vs. 341.00 (177-734) mg/g, p <0.001). Moreover, those patients with more haematuria intensity had a higher urinary protein:creatinine ratio (1352.65 (665-2292) vs. 849.60 (562-1155) mg/g, p = 0.02). Those patients with higher proteinuria were more likely to need renal replacement therapy (22.7 vs. 0%, p = 0.03) and to suffer relapse (4 vs. 0%, p = 0.03). At the end of follow up, haematuric ATIN patients had higher serum creatinine levels (3.19 ± 2.91 vs. 1.91 ± 1.17 mg/dL, p = 0.007), and a trend towards a higher need for acute dialysis (7 vs. 1%, p = 0.09) and renal replacement therapy (12.1 vs. 2.3%, p = 0.12). Haematuria is common in ATIN and it is associated with worse renal function outcomes.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article