Your browser doesn't support javascript.
loading
Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine ß-Lactamases.
Durand-Réville, Thomas F; Comita-Prevoir, Janelle; Zhang, Jing; Wu, Xiaoyun; May-Dracka, Tricia L; Romero, Jan Antoinette C; Wu, Frank; Chen, April; Shapiro, Adam B; Carter, Nicole M; McLeod, Sarah M; Giacobbe, Robert A; Verheijen, Jeroen C; Lahiri, Sushmita D; Sacco, Michael D; Chen, Yu; O'Donnell, John P; Miller, Alita A; Mueller, John P; Tommasi, Rubén A.
Afiliação
  • Durand-Réville TF; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Comita-Prevoir J; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Zhang J; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Wu X; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • May-Dracka TL; Infection Discovery, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Romero JAC; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Wu F; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Chen A; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Shapiro AB; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Carter NM; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • McLeod SM; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Giacobbe RA; Infection Discovery, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Verheijen JC; Infection Discovery, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Lahiri SD; Infection Discovery, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Sacco MD; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, Florida 33612, United States.
  • Chen Y; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, Florida 33612, United States.
  • O'Donnell JP; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Miller AA; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Mueller JP; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Tommasi RA; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
J Med Chem ; 63(21): 12511-12525, 2020 11 12.
Article em En | MEDLINE | ID: mdl-32658473
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Compostos Azabicíclicos / Inibidores de beta-Lactamases / Antibacterianos Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Compostos Azabicíclicos / Inibidores de beta-Lactamases / Antibacterianos Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article