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Distinct subnetworks of the thalamic reticular nucleus.
Li, Yinqing; Lopez-Huerta, Violeta G; Adiconis, Xian; Levandowski, Kirsten; Choi, Soonwook; Simmons, Sean K; Arias-Garcia, Mario A; Guo, Baolin; Yao, Annie Y; Blosser, Timothy R; Wimmer, Ralf D; Aida, Tomomi; Atamian, Alexander; Naik, Tina; Sun, Xuyun; Bi, Dasheng; Malhotra, Diya; Hession, Cynthia C; Shema, Reut; Gomes, Marcos; Li, Taibo; Hwang, Eunjin; Krol, Alexandra; Kowalczyk, Monika; Peça, João; Pan, Gang; Halassa, Michael M; Levin, Joshua Z; Fu, Zhanyan; Feng, Guoping.
Afiliação
  • Li Y; School of Pharmaceutical Sciences, IDG/McGovern Institute for Brain Research, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, P. R. China.
  • Lopez-Huerta VG; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Adiconis X; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Levandowski K; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Choi S; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Simmons SK; Institute of Cellular Physiology, National Autonomous University of Mexico, Mexico City, Mexico.
  • Arias-Garcia MA; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Guo B; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Yao AY; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Blosser TR; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Wimmer RD; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Aida T; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Atamian A; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Naik T; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Sun X; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bi D; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Malhotra D; Faculty of Psychology, National Autonomous University of Mexico, Mexico City, Mexico.
  • Hession CC; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Shema R; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Gomes M; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Li T; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Hwang E; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Krol A; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kowalczyk M; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Peça J; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Pan G; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Halassa MM; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Levin JZ; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Fu Z; The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Feng G; McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nature ; 583(7818): 819-824, 2020 07.
Article em En | MEDLINE | ID: mdl-32699411
ABSTRACT
The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, regulates thalamocortical interactions that are critical for sensory processing, attention and cognition1-5. TRN dysfunction has been linked to sensory abnormality, attention deficit and sleep disturbance across multiple neurodevelopmental disorders6-9. However, little is known about the organizational principles that underlie its divergent functions. Here we performed an integrative study linking single-cell molecular and electrophysiological features of the mouse TRN to connectivity and systems-level function. We found that cellular heterogeneity in the TRN is characterized by a transcriptomic gradient of two negatively correlated gene-expression profiles, each containing hundreds of genes. Neurons in the extremes of this transcriptomic gradient express mutually exclusive markers, exhibit core or shell-like anatomical structure and have distinct electrophysiological properties. The two TRN subpopulations make differential connections with the functionally distinct first-order and higher-order thalamic nuclei to form molecularly defined TRN-thalamus subnetworks. Selective perturbation of the two subnetworks in vivo revealed their differential role in regulating sleep. In sum, our study provides a comprehensive atlas of TRN neurons at single-cell resolution and links molecularly defined subnetworks to the functional organization of thalamocortical circuits.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Núcleos Talâmicos / Redes Reguladoras de Genes Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Núcleos Talâmicos / Redes Reguladoras de Genes Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article