Mediator complex subunit Med19 binds directly GATA transcription factors and is required with Med1 for GATA-driven gene regulation <i>in vivo</i>.

Immarigeon, Clément; Bernat-Fabre, Sandra; Guillou, Emmanuelle; Verger, Alexis; Prince, Elodie; Benmedjahed, Mohamed A; Payet, Adeline; Couralet, Marie; Monte, Didier; Villeret, Vincent; Bourbon, Henri-Marc; Boube, Muriel

Mediator complex subunit Med19 binds directly GATA transcription factors and is required with Med1 for GATA-driven gene regulation in vivo.

Immarigeon, Clément; Bernat-Fabre, Sandra; Guillou, Emmanuelle; Verger, Alexis; Prince, Elodie; Benmedjahed, Mohamed A; Payet, Adeline; Couralet, Marie; Monte, Didier; Villeret, Vincent; Bourbon, Henri-Marc; Boube, Muriel.

Afiliação

Immarigeon C; Centre de Biologie Integrative CBD, UMR5547 CNRS/UPS, Université de Toulouse, Toulouse Cedex, France.
Bernat-Fabre S; Centre de Biologie Integrative CBD, UMR5547 CNRS/UPS, Université de Toulouse, Toulouse Cedex, France.
Guillou E; Centre de Biologie Integrative CBD, UMR5547 CNRS/UPS, Université de Toulouse, Toulouse Cedex, France.
Verger A; Inserm, CHU Lille, Institut Pasteur de Lille, CNRS ERL 9002 Integrative Structural Biology, Université Lille, Lille, France.
Prince E; Centre de Biologie Integrative CBD, UMR5547 CNRS/UPS, Université de Toulouse, Toulouse Cedex, France.
Benmedjahed MA; Centre de Biologie Integrative CBD, UMR5547 CNRS/UPS, Université de Toulouse, Toulouse Cedex, France.
Payet A; Centre de Biologie Integrative CBD, UMR5547 CNRS/UPS, Université de Toulouse, Toulouse Cedex, France.
Couralet M; Centre de Biologie Integrative CBD, UMR5547 CNRS/UPS, Université de Toulouse, Toulouse Cedex, France.
Monte D; Inserm, CHU Lille, Institut Pasteur de Lille, CNRS ERL 9002 Integrative Structural Biology, Université Lille, Lille, France.
Villeret V; Inserm, CHU Lille, Institut Pasteur de Lille, CNRS ERL 9002 Integrative Structural Biology, Université Lille, Lille, France.
Bourbon HM; Centre de Biologie Integrative CBD, UMR5547 CNRS/UPS, Université de Toulouse, Toulouse Cedex, France.
Boube M; Centre de Biologie Integrative CBD, UMR5547 CNRS/UPS, Université de Toulouse, Toulouse Cedex, France. Electronic address: muriel.boube-trey@univ-tlse3.fr.

J Biol Chem ; 295(39): 13617-13629, 2020 09 25.

Article em En | MEDLINE | ID: mdl-32737196

Assuntos

Proteínas de Drosophila/metabolismo; Fatores de Transcrição GATA/metabolismo; Complexo Mediador/metabolismo; Animais; Sítios de Ligação; Proteínas de Drosophila/genética; Drosophila melanogaster; Fatores de Transcrição GATA/genética; Regulação da Expressão Gênica/genética

Palavras-chave

Activation domain; DNA-binding domain; Drosophila development; GATA transcription factor; GATA transcription factors; Med1; Med19; Pannier; Pnr; Serpent; Srp; cofactor; drosophila genetics; gene regulation; mediator complex; thoracic closure; transcription coregulator; transcription regulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Drosophila / Fatores de Transcrição GATA / Complexo Mediador Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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