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An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
Zarantonello, Alessandra; Presumey, Jessy; Simoni, Léa; Yalcin, Esra; Fox, Rachel; Hansen, Annette; Olesen, Heidi Gytz; Thiel, Steffen; Johnson, Matthew B; Stevens, Beth; Laursen, Nick Stub; Carroll, Michael C; Andersen, Gregers R.
Afiliação
  • Zarantonello A; Department of Molecular Biology and Genetics, Aarhus University, DK8000 Aarhus, Denmark.
  • Presumey J; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
  • Simoni L; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
  • Yalcin E; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
  • Fox R; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
  • Hansen A; Department of Biomedicine, Aarhus University, DK8000 Aarhus, Denmark.
  • Olesen HG; Department of Molecular Biology and Genetics, Aarhus University, DK8000 Aarhus, Denmark.
  • Thiel S; Department of Biomedicine, Aarhus University, DK8000 Aarhus, Denmark.
  • Johnson MB; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
  • Stevens B; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.
  • Laursen NS; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
  • Carroll MC; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.
  • Andersen GR; Department of Neurology, Harvard Medical School, Boston, MA 02115.
J Immunol ; 205(6): 1678-1694, 2020 09 15.
Article em En | MEDLINE | ID: mdl-32769120
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Complemento C3 / Complemento C4b / Convertases de Complemento C3-C5 da Via Clássica / Células-Tronco Pluripotentes Induzidas / Anticorpos de Domínio Único / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Complemento C3 / Complemento C4b / Convertases de Complemento C3-C5 da Via Clássica / Células-Tronco Pluripotentes Induzidas / Anticorpos de Domínio Único / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article