Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.

Hoffmann, Markus; Hofmann-Winkler, Heike; Smith, Joan C; Krüger, Nadine; Sørensen, Lambert K; Søgaard, Ole S; Hasselstrøm, Jørgen Bo; Winkler, Michael; Hempel, Tim; Raich, Lluís; Olsson, Simon; Yamazoe, Takashi; Yamatsuta, Katsura; Mizuno, Hirotaka; Ludwig, Stephan; Noé, Frank; Sheltzer, Jason M; Kjolby, Mads; Pöhlmann, Stefan

Hoffmann, Markus; Hofmann-Winkler, Heike; Smith, Joan C; Krüger, Nadine; Sørensen, Lambert K; Søgaard, Ole S; Hasselstrøm, Jørgen Bo; Winkler, Michael; Hempel, Tim; Raich, Lluís; Olsson, Simon; Yamazoe, Takashi; Yamatsuta, Katsura; Mizuno, Hirotaka; Ludwig, Stephan; Noé, Frank; Sheltzer, Jason M; Kjolby, Mads; Pöhlmann, Stefan.

Afiliação

Hoffmann M; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
Hofmann-Winkler H; Faculty of Biology and Psychology, University Göttingen, 37073 Göttingen, Germany.
Smith JC; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
Krüger N; Google, Inc., New York City, NY 10011, USA.
Sørensen LK; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Søgaard OS; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
Hasselstrøm JB; Department of Forensic Medicine, Aarhus University, Denmark.
Winkler M; Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.
Hempel T; Department of Infectious Diseases, Aarhus University Hospital, 8200 Aarhus, Denmark.
Raich L; Department of Forensic Medicine, Aarhus University, Denmark.
Olsson S; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
Yamazoe T; Freie Universität Berlin, Department of Mathematics and Computer Science, Berlin, Germany.
Yamatsuta K; Freie Universität Berlin, Department of Physics, Berlin, Germany.
Mizuno H; Freie Universität Berlin, Department of Mathematics and Computer Science, Berlin, Germany.
Ludwig S; Freie Universität Berlin, Department of Mathematics and Computer Science, Berlin, Germany.
Noé F; Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan.
Sheltzer JM; Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan.
Kjolby M; Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan.
Pöhlmann S; Institute of Virology (IVM), Westfälische Wilhelms-Universität, 48149 Münster, Germany.

bioRxiv ; 2020 Aug 05.

Article em En | MEDLINE | ID: mdl-32793911

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article