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The PI3Kα inhibitor DFX24 suppresses tumor growth and metastasis in non-small cell lung cancer via ERK inhibition and EPHB6 reactivation.
Fan, Yan-Hua; Ding, Huai-Wei; Kim, Donghwa; Liu, Jian-Yu; Hong, Ji-Young; Xu, Yong-Nan; Wang, Daoping; Yang, Xiao-Sheng; Lee, Sang Kook.
Afiliação
  • Fan YH; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
  • Ding HW; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Kim D; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, South Korea.
  • Liu JY; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Hong JY; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, South Korea.
  • Xu YN; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Wang D; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
  • Yang XS; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China. Electronic address: gzcnp@sina.cn.
  • Lee SK; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, South Korea. Electronic address: sklee61@snu.ac.kr.
Pharmacol Res ; 160: 105147, 2020 10.
Article em En | MEDLINE | ID: mdl-32814167
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Quinazolinas / Sulfonamidas / Derivados de Benzeno / Morfolinas / Carcinoma Pulmonar de Células não Pequenas / Fosfatidilinositol 3-Quinases / Sistema de Sinalização das MAP Quinases / Receptores da Família Eph / Inibidores de Proteínas Quinases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Quinazolinas / Sulfonamidas / Derivados de Benzeno / Morfolinas / Carcinoma Pulmonar de Células não Pequenas / Fosfatidilinositol 3-Quinases / Sistema de Sinalização das MAP Quinases / Receptores da Família Eph / Inibidores de Proteínas Quinases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article