Saikosaponin d contributed to cancer chemotherapy induced neutropenia therapy by promoting neutrophil differentiation via activation CBL-dependent ERK pathway.

Qi, Xiaotian; Fan, Mengyue; Huang, Nana; Zhang, Xinyu; Liu, Jing; Li, Xiaoyu; Sun, Rong

Qi, Xiaotian; Fan, Mengyue; Huang, Nana; Zhang, Xinyu; Liu, Jing; Li, Xiaoyu; Sun, Rong.

Afiliação

Qi X; Institute of Advanced Medical Research, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Fan M; Institute of Advanced Medical Research, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, China.
Huang N; Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, China.
Zhang X; Institute of Advanced Medical Research, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, China.
Liu J; Institute of Advanced Medical Research, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, China.
Li X; Department of Medical Pathomorphology, Shandong Academy of Traditional Chinese Medicine, Jinan, 250014, Shandong, China.
Sun R; Institute of Advanced Medical Research, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, China. Electronic address: sunrong107@163.com.

Pharmacol Res ; 160: 105149, 2020 10.

Article em En | MEDLINE | ID: mdl-32822868

Assuntos

Antineoplásicos/efeitos adversos; Fatores Imunológicos/uso terapêutico; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Ativação de Macrófagos/efeitos dos fármacos; Neutropenia/induzido quimicamente; Neutropenia/tratamento farmacológico; Neutrófilos/efeitos dos fármacos; Ácido Oleanólico/análogos & derivados; Proteína Oncogênica v-cbl/efeitos dos fármacos; Saponinas/uso terapêutico; Animais; Atividade Bactericida do Sangue; Proteína beta Intensificadora de Ligação a CCAAT/efeitos dos fármacos; Diferenciação Celular/efeitos dos fármacos; Controle de Infecções; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Ácido Oleanólico/uso terapêutico

Palavras-chave

CBL; Cancer chemotherapy induced neutropenia; ERK1/2; Network pharmacology; Neutrophil bactericidal activity; Saikosaponin d; Saikosaponin d (PubChem CID 107793)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Oleanólico / Saponinas / Sistema de Sinalização das MAP Quinases / Proteína Oncogênica v-cbl / Fatores Imunológicos / Ativação de Macrófagos / Neutropenia / Neutrófilos / Antineoplásicos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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