Impact of Prior Ischemic Stroke on Outcomes in Patients With Heart Failureã- A Propensity-Matched Study.
Circ J
; 84(10): 1797-1806, 2020 09 25.
Article
em En
| MEDLINE
| ID: mdl-32893260
ABSTRACT
BACKGROUND:
Whether ischemic stroke per se, rather than older age or additional comorbidities, accounts for the adverse prognosis of heart failure (HF) is uncertain. The present study examineed the intrinsic association of ischemic stroke with outcomes in a propensity-matched cohort.MethodsâandâResults:
Of 1,351 patients hospitalized with HF, 388 (28.7%) had prior ischemic stroke. Using propensity score for prior ischemic stroke, estimated for each patient, a matched cohort of 379 pairs of HF patients with and without prior ischemic stroke, balanced on 32 baseline characteristics was assembled. At 30 days, prior ischemic stroke was associated with significantly higher risks of the combined endpoint of all-cause death or readmission (hazard ratio [HR] 1.91; 95% confidence interval [CI] 1.38 to 2.65; P<0.001), all-cause death (HR 2.08; 95% CI 1.28 to 3.38; P=0.003), all-cause readmission (HR 2.67; 95% CI 1.78 to 4.01; P<0.001), and HF readmission (HR 2.11; 95% CI 1.19 to 3.72; P=0.010). Prior ischemic stroke was associated with a significantly higher risk of all 4 outcomes at both 6 months and 1 year.CONCLUSIONS:
Prior ischemic stroke was a potent and persistent risk predictor of death and readmission among patients with HF after accounting for clinical characteristics.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Readmissão do Paciente
/
Pontuação de Propensão
/
AVC Isquêmico
/
Insuficiência Cardíaca
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article