Dynamic Contrast-Enhanced Magnetic Resonance Imaging as Imaging Biomarker for Vascular Normalization Effect of Infigratinib in High-FGFR-Expressing Hepatocellular Carcinoma Xenografts.

Tran, Anh; Koh, Tong San; Prawira, Aldo; Ho, Rebecca Zhi Wen; Le, Thi Bich Uyen; Vu, Thanh Chung; Hartano, Septian; Teo, Xing Qi; Chen, Way Cherng; Lee, Philip; Thng, Choon Hua; Huynh, Hung

Tran, Anh; Koh, Tong San; Prawira, Aldo; Ho, Rebecca Zhi Wen; Le, Thi Bich Uyen; Vu, Thanh Chung; Hartano, Septian; Teo, Xing Qi; Chen, Way Cherng; Lee, Philip; Thng, Choon Hua; Huynh, Hung.

Afiliação

Tran A; Department of Oncologic Imaging, National Cancer Centre, Singapore, Singapore.
Koh TS; Department of Oncologic Imaging, National Cancer Centre, Singapore, Singapore.
Prawira A; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore.
Ho RZW; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore.
Le TBU; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore.
Vu TC; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore.
Hartano S; Department of Oncologic Imaging, National Cancer Centre, Singapore, Singapore.
Teo XQ; Functional Metabolism Group, Agency for Science, Technology and Research, Singapore BioImaging Consortium, Singapore, Singapore.
Chen WC; Bruker Singapore Pte Ltd, Singapore, Singapore.
Lee P; Functional Metabolism Group, Agency for Science, Technology and Research, Singapore BioImaging Consortium, Singapore, Singapore.
Thng CH; Department of Oncologic Imaging, National Cancer Centre, Singapore, Singapore. thng.choon.hua@singhealth.com.sg.
Huynh H; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore. cmrhth@nccs.com.sg.

Mol Imaging Biol ; 23(1): 70-83, 2021 02.

Article em En | MEDLINE | ID: mdl-32909245

Assuntos

Biomarcadores Tumorais/metabolismo; Carcinoma Hepatocelular/tratamento farmacológico; Meios de Contraste/química; Neoplasias Hepáticas/tratamento farmacológico; Imageamento por Ressonância Magnética; Neovascularização Patológica/tratamento farmacológico; Compostos de Fenilureia/uso terapêutico; Pirimidinas/uso terapêutico; Receptores de Fatores de Crescimento de Fibroblastos/metabolismo; Animais; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Apoptose/efeitos dos fármacos; Carcinoma Hepatocelular/irrigação sanguínea; Proliferação de Células/efeitos dos fármacos; Humanos; Cinética; Neoplasias Hepáticas/irrigação sanguínea; Camundongos SCID; Perfusão; Sorafenibe/farmacologia; Sorafenibe/uso terapêutico; Microambiente Tumoral/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Biomarker; DCE-MRI; FGFR; HCC; Vascular normalization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Pirimidinas / Imageamento por Ressonância Magnética / Biomarcadores Tumorais / Receptores de Fatores de Crescimento de Fibroblastos / Carcinoma Hepatocelular / Meios de Contraste / Neoplasias Hepáticas / Neovascularização Patológica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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