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Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective.
Reynolds, Vincent L; Butler, Paul; Abernathy, Matthew M; Aschenbrenner, Laura; Best, Derek D; Blank, Jim; Crosby, Meredith; Custer, Laura; Escobar, Patricia A; Kolaja, Kyle; Moggs, Jonathan; Shuey, Dana; Snyder, Chelsea; Van Vleet, Terry; Zhou, Junguo; Hart, Timothy K.
Afiliação
  • Reynolds VL; Lilly Research Laboratories, Indianapolis, IN, USA. Electronic address: reynolds_vincent_l@lilly.com.
  • Butler P; Pfizer Inc., San Diego, CA, USA.
  • Abernathy MM; Lilly Research Laboratories, Indianapolis, IN, USA.
  • Aschenbrenner L; Pfizer Inc., San Diego, CA, USA.
  • Best DD; Lilly Research Laboratories, Indianapolis, IN, USA.
  • Blank J; Takeda Pharmaceutical, Cambridge, MA, USA.
  • Crosby M; AbbVie Inc. Global Pharmaceutical Research and Development, Preclinical Safety, 1 North Waukegan Road, North Chicago, IL, USA.
  • Custer L; Bristol-Myers Squibb, Drug Safety Evaluation, 1 Squibb Dr, New Brunswick, NJ, USA.
  • Escobar PA; Merck Sharp & Dohme Corp, West Point, PA, USA.
  • Kolaja K; Bristol-Myers Squibb, Drug Safety Evaluation, 1 Squibb Dr, New Brunswick, NJ, USA.
  • Moggs J; Novartis Institutes for BioMedical Research, Translational Medicine, Basel, Switzerland.
  • Shuey D; Incyte Corporation, 1801 Augustine Cutoff, Wilmington, DE, USA.
  • Snyder C; Gilead Sciences, Foster City, CA, USA.
  • Van Vleet T; AbbVie Inc. Global Pharmaceutical Research and Development, Preclinical Safety, 1 North Waukegan Road, North Chicago, IL, USA.
  • Zhou J; Nonclinical Safety, Janssen Research and Development LLC., Raritan, NJ, USA.
  • Hart TK; GlaxoSmithKline, 1250 S Collegeville Rd, Collegeville, PA, USA.
Regul Toxicol Pharmacol ; 117: 104746, 2020 Nov.
Article em En | MEDLINE | ID: mdl-32911461
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Inquéritos e Questionários / Epigênese Genética / Controle de Medicamentos e Entorpecentes / Indústria Farmacêutica Tipo de estudo: Etiology_studies / Guideline / Qualitative_research / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Inquéritos e Questionários / Epigênese Genética / Controle de Medicamentos e Entorpecentes / Indústria Farmacêutica Tipo de estudo: Etiology_studies / Guideline / Qualitative_research / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article