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Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm.
Bocková, Martina; Lamos, Martin; Klimes, Petr; Jurák, Pavel; Halámek, Josef; Goldemundová, Sabina; Baláz, Marek; Rektor, Ivan.
Afiliação
  • Bocková M; Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Brno, Czech Republic.
  • Lamos M; First Department of Neurology, Medical Faculty of Masaryk University, Movement Disorders Center, Masaryk University School of Medicine, St. Anne's Hospital, Pekarská 53, 656 91, Brno, Czech Republic.
  • Klimes P; Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Brno, Czech Republic.
  • Jurák P; Institute of Scientific Instruments of the Czech Academy of Sciences, V.V.I., Brno, Czech Republic.
  • Halámek J; Institute of Scientific Instruments of the Czech Academy of Sciences, V.V.I., Brno, Czech Republic.
  • Goldemundová S; Institute of Scientific Instruments of the Czech Academy of Sciences, V.V.I., Brno, Czech Republic.
  • Baláz M; Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Brno, Czech Republic.
  • Rektor I; Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Brno, Czech Republic.
J Neural Transm (Vienna) ; 127(12): 1579-1588, 2020 12.
Article em En | MEDLINE | ID: mdl-32965592
Although deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) is generally a successful therapy, adverse events and insufficient clinical effect can complicate the treatment in some patients. We studied clinical parameters and cortical oscillations related to STN-DBS to identify patients with suboptimal responses. High-density EEG was recorded during a visual oddball three-stimuli paradigm in DBS "off" and "on" conditions in 32 PD patients with STN-DBS. Pre-processed data were reconstructed into the source space and the time-frequency analysis was evaluated. We identified a subgroup of six patients with longer reaction times (RT) during the DBS "on" state than in the DBS "off" state after target stimuli. These subjects had lower motor responsiveness to DBS and decreased memory test results compared to the other subjects. Moreover, the alpha and beta power decrease (event-related desynchronizations, ERD), known as an activation correlate linked to motor and cognitive processing, was also reduced in the DBS "on" condition in these patients. A subgroup of PD patients with a suboptimal response to STN-DBS was identified. Evaluation of RT could potentially serve as a biomarker for responsiveness to STN-DBS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Núcleo Subtalâmico / Estimulação Encefálica Profunda Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Núcleo Subtalâmico / Estimulação Encefálica Profunda Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article