Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a-synuclein in mouse brain.

Samantha Sykioti, Vasia; Karampetsou, Mantia; Chalatsa, Ioanna; Polissidis, Alexia; Michael, Iacovos P; Pagaki-Skaliora, Marina; Nagy, Andras; Emmanouilidou, Evangelia; Sotiropoulou, Georgia; Vekrelli S, Kostas

Samantha Sykioti, Vasia; Karampetsou, Mantia; Chalatsa, Ioanna; Polissidis, Alexia; Michael, Iacovos P; Pagaki-Skaliora, Marina; Nagy, Andras; Emmanouilidou, Evangelia; Sotiropoulou, Georgia; Vekrelli S, Kostas.

Afiliação

Samantha Sykioti V; Center for Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.
Karampetsou M; Center for Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.
Chalatsa I; Center for Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.
Polissidis A; Laboratory of Biochemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis, Athens, Greece.
Michael IP; Center for Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.
Pagaki-Skaliora M; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Nagy A; Center for Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.
Emmanouilidou E; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Sotiropoulou G; Department of Obstetrics and Gynaecology, Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Vekrelli S K; Center for Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.

J Neurochem ; 157(6): 2024-2038, 2021 06.

Article em En | MEDLINE | ID: mdl-32974895

Assuntos

Encéfalo/metabolismo; Encéfalo/patologia; Calicreínas/deficiência; Sinucleinopatias/metabolismo; Sinucleinopatias/patologia; alfa-Sinucleína/metabolismo; Animais; Células Cultivadas; Feminino; Calicreínas/genética; Masculino; Aprendizagem em Labirinto/fisiologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Sinucleinopatias/genética; alfa-Sinucleína/genética

Palavras-chave

alpha-synuclein; clearance; kalikrein 6 peptidase; microdialysis; synucleinopathies; transmission

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Calicreínas / Alfa-Sinucleína / Sinucleinopatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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