EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism.

Ramamoorthy, Senthilkumar; Kometani, Kohei; Herman, Josip S; Bayer, Marc; Boller, Sören; Edwards-Hicks, Joy; Ramachandran, Haribaskar; Li, Rui; Klein-Geltink, Ramon; Pearce, Erika L; Grün, Dominic; Grosschedl, Rudolf

Ramamoorthy, Senthilkumar; Kometani, Kohei; Herman, Josip S; Bayer, Marc; Boller, Sören; Edwards-Hicks, Joy; Ramachandran, Haribaskar; Li, Rui; Klein-Geltink, Ramon; Pearce, Erika L; Grün, Dominic; Grosschedl, Rudolf.

Afiliação

Ramamoorthy S; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Kometani K; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Herman JS; Laboratory of Single-Cell Biology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Bayer M; International Max Planck Research School, University of Freiburg, 79104 Freiburg, Germany.
Boller S; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Edwards-Hicks J; International Max Planck Research School, University of Freiburg, 79104 Freiburg, Germany.
Ramachandran H; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Li R; Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Klein-Geltink R; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Pearce EL; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Grün D; Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Grosschedl R; Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.

Genes Dev ; 34(21-22): 1503-1519, 2020 11 01.

Article em En | MEDLINE | ID: mdl-33004416

Assuntos

Ácido Fólico/metabolismo; Interleucina-7/fisiologia; Fator de Transcrição PAX5/metabolismo; Leucemia-Linfoma Linfoblástico de Células Precursoras/fisiopatologia; Proteínas Proto-Oncogênicas c-myc/genética; Transdução de Sinais/genética; Transativadores/metabolismo; Animais; Carbono/metabolismo; Sobrevivência Celular/genética; Transformação Celular Neoplásica/genética; Modelos Animais de Doenças; Regulação Neoplásica da Expressão Gênica/genética; Redes Reguladoras de Genes/genética; Camundongos; Fator de Transcrição PAX5/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Células Precursoras de Linfócitos B/patologia; Ligação Proteica; Análise de Célula Única; Transativadores/genética

Palavras-chave

B-ALL; EBF1; IL-7 signaling; Pax5; cMyc; folate pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Transativadores / Proteínas Proto-Oncogênicas c-myc / Interleucina-7 / Fator de Transcrição PAX5 / Leucemia-Linfoma Linfoblástico de Células Precursoras / Ácido Fólico Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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