Depression Is Associated With Preserved Cortical Thickness Relative to Apathy in Frontotemporal Dementia.
J Geriatr Psychiatry Neurol
; 35(1): 78-88, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-33030106
ABSTRACT
OBJECTIVES:
To understand the differential neuroanatomical substrates underlying apathy and depression in Frontotemporal dementia (FTD).METHODS:
T1-MRIs and clinical data of patients with behavioral and aphasic variants of FTD were obtained from an open database. Cortical thickness was derived, its association with apathy severity and difference between the depressed and not depressed were examined with appropriate covariates.RESULTS:
Apathy severity was significantly associated with cortical thinning of the lateral parts of the right sided frontal, temporal and parietal lobes. The right sided orbitofrontal, parsorbitalis and rostral anterior cingulate cortex were thicker in depressed compared to patients not depressed.CONCLUSIONS:
Greater thickness of right sided ventromedial and inferior frontal cortex in depression compared to patients without depression suggests a possible requisite of gray matter in this particular area for the manifestation of depression in FTD. This study demonstrates a method for deriving neuroanatomical patterns across non-harmonized neuroimaging data in a neurodegenerative disease.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Neurodegenerativas
/
Demência Frontotemporal
/
Apatia
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article