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Brain-derived neurotrophic factor (BDNF) is associated with depressive symptoms in older adults with HIV disease.
Woods, Steven Paul; Babicz, Michelle; Shahani, Lokesh; Colpo, Gabriela Delevati; Morgan, Erin E; Teixeira, Antonio L.
Afiliação
  • Woods SP; Department of Psychology, University of Houston, 126 Heyne Bldg., Houston, TX, 77004, USA. spwoods@uh.edu.
  • Babicz M; Department of Psychology, University of Houston, 126 Heyne Bldg., Houston, TX, 77004, USA.
  • Shahani L; Neuropsychiatry Program, Department of Psychiatry & Behavioral Science, University of Texas Health Sciences Center At Houston, Houston, TX, 77204, USA.
  • Colpo GD; Neuropsychiatry Program, Department of Psychiatry & Behavioral Science, University of Texas Health Sciences Center At Houston, Houston, TX, 77204, USA.
  • Morgan EE; Department of Psychiatry, University of California, San Diego, CA, USA.
  • Teixeira AL; Neuropsychiatry Program, Department of Psychiatry & Behavioral Science, University of Texas Health Sciences Center At Houston, Houston, TX, 77204, USA.
J Neurovirol ; 27(1): 70-79, 2021 02.
Article em En | MEDLINE | ID: mdl-33145707
ABSTRACT
Symptoms of depression are common among persons with HIV (PWH) and can have a significant impact on socioeconomic and personal well-being, but little is known about their neurobiological substrates in the context of HIV disease. This study examined the possible role of brain-derived neurotrophic factor (BDNF) in symptoms of depression and other aspects of mood in 109 PWH and 43 seronegative participants aged 50 and older. Participants completed the Profile of Mood States (POMS) which measured six dimensions of mood and was normatively adjusted for sex. A model controlling for medical comorbidities and substance use diagnoses among PWH showed a significant interaction between BDNF and POMS subscales. Planned post hoc analyses revealed that lower BDNF was only associated with higher scores on Depression-Dejection and Confusion-Bewilderment POMS subscales among PWH and at small-to-medium effect sizes. Lower levels of BDNF were associated with AIDS diagnoses and CD4 count, but not with viremia or duration of infection. BDNF levels did not differ between the PWH and HIV - samples, and there were no significant correlations between BDNF and any POMS variable in the HIV - group. Findings implicate BDNF in the neuropathophysiology of specific depressive symptoms in the context of HIV disease. Future studies may examine whether BDNF levels change over time, are sensitive to other aspects of mood disorders in HIV, and are associated with markers of HIV-associated neural injury.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Fator Neurotrófico Derivado do Encéfalo / Depressão Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Fator Neurotrófico Derivado do Encéfalo / Depressão Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article