Peptide-MHC Binding Reveals Conserved Allosteric Sites in MHC Class I- and Class II-Restricted T Cell Receptors (TCRs).

He, Yanan; Agnihotri, Pragati; Rangarajan, Sneha; Chen, Yihong; Kerzic, Melissa C; Ma, Buyong; Nussinov, Ruth; Mariuzza, Roy A; Orban, John

He, Yanan; Agnihotri, Pragati; Rangarajan, Sneha; Chen, Yihong; Kerzic, Melissa C; Ma, Buyong; Nussinov, Ruth; Mariuzza, Roy A; Orban, John.

Afiliação

He Y; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Agnihotri P; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Rangarajan S; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Chen Y; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Kerzic MC; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Ma B; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, US
Nussinov R; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Mariuzza RA; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA. Electronic address: rmariuzz@umd.edu.
Orban J; W.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA. Electronic address: jorban@umd.edu.

J Mol Biol ; 432(24): 166697, 2020 12 04.

Article em En | MEDLINE | ID: mdl-33157083

Assuntos

Antígenos de Histocompatibilidade Classe II/imunologia; Antígenos de Histocompatibilidade Classe I/imunologia; Peptídeos/imunologia; Receptores de Antígenos de Linfócitos T alfa-beta/imunologia; Sítio Alostérico/genética; Sítios de Ligação/genética; Sequência Conservada/genética; Antígeno HLA-DR4/genética; Antígeno HLA-DR4/imunologia; Antígenos de Histocompatibilidade Classe I/genética; Antígenos de Histocompatibilidade Classe II/genética; Humanos; Simulação de Dinâmica Molecular; Peptídeos/genética; Ligação Proteica/genética; Conformação Proteica; Complexo Receptor-CD3 de Antígeno de Linfócitos T/imunologia; Receptores de Antígenos de Linfócitos T alfa-beta/genética; Linfócitos T/imunologia

Palavras-chave

Allostery; NMR; T cell receptor; T cell triggering; peptideMHC

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Antígenos de Histocompatibilidade Classe I / Antígenos de Histocompatibilidade Classe II / Receptores de Antígenos de Linfócitos T alfa-beta Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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