The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease.
Curr Opin Immunol
; 68: 116-124, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33181351
ABSTRACT
To maintain homeostasis, an organism must detect and resolve sterile tissue damage. The NLRP3 inflammasome coordinates such processes to clear tissue damage and induce repair. Dysregulated NLRP3 inflammasome activity, however, drives many conditions including Alzheimer's disease (AD). Recent reports posit that ß-amyloid and tau aggregates trigger destructive NLRP3 inflammasome signalling in the brain, leading to AD pathophysiology and cognitive decline. Other endogenous molecules (e.g. TNF, ATP, serum amyloid A), as well as dysbiosis, can induce peripheral or central inflammation and thereby promote microglial NLRP3 inflammasome signalling and resultant AD. The NLRP3 inflammasome is thus emerging as a critical driver of sterile neuroinflammation and the resultant pathogenesis and progression of AD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inflamassomos
/
Doença de Alzheimer
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Proteína 3 que Contém Domínio de Pirina da Família NLR
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article