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Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies.
Mayrhofer, Johanna E; Enzler, Florian; Feichtner, Andreas; Röck, Ruth; Fleischmann, Jakob; Raffeiner, Andrea; Tschaikner, Philipp; Ogris, Egon; Huber, Roland G; Hartl, Markus; Schneider, Rainer; Troppmair, Jakob; Torres-Quesada, Omar; Stefan, Eduard.
Afiliação
  • Mayrhofer JE; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria.
  • Enzler F; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria.
  • Feichtner A; Daniel Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
  • Röck R; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria.
  • Fleischmann J; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria.
  • Raffeiner A; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria.
  • Tschaikner P; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria.
  • Ogris E; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria.
  • Huber RG; Institute of Molecular Biology, University of Innsbruck, 6020 Innsbruck, Austria.
  • Hartl M; Center for Medical Biochemistry, Max Perutz Labs, Medical University of Vienna, A-1030 Vienna, Austria.
  • Schneider R; Bioinformatics Institute, Agency for Science Technology and Research, 138671 Singapore, Singapore.
  • Troppmair J; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria.
  • Torres-Quesada O; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria.
  • Stefan E; Daniel Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Proc Natl Acad Sci U S A ; 117(49): 31105-31113, 2020 12 08.
Article em En | MEDLINE | ID: mdl-33229534
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Conformação Proteica / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Conformação Proteica / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article