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MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects.
Verma, Vivek; Jafarzadeh, Nazli; Boi, Shannon; Kundu, Subhadip; Jiang, Zhinuo; Fan, Yiping; Lopez, Jose; Nandre, Rahul; Zeng, Peng; Alolaqi, Fatmah; Ahmad, Shamim; Gaur, Pankaj; Barry, Simon T; Valge-Archer, Viia E; Smith, Paul D; Banchereau, Jacques; Mkrtichyan, Mikayel; Youngblood, Benjamin; Rodriguez, Paulo C; Gupta, Seema; Khleif, Samir N.
Afiliação
  • Verma V; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
  • Jafarzadeh N; Georgia Cancer Center, Augusta University, Augusta, GA, USA.
  • Boi S; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
  • Kundu S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Jiang Z; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
  • Fan Y; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
  • Lopez J; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Nandre R; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
  • Zeng P; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
  • Alolaqi F; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD, USA.
  • Ahmad S; Georgia Cancer Center, Augusta University, Augusta, GA, USA.
  • Gaur P; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA.
  • Barry ST; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
  • Valge-Archer VE; Georgia Cancer Center, Augusta University, Augusta, GA, USA.
  • Smith PD; Kite Pharma/A GILEAD Company, Emeryville, CA, USA.
  • Banchereau J; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
  • Mkrtichyan M; Bioscience, Early Oncology, AstraZeneca, Cambridge, UK.
  • Youngblood B; Bioscience, Early Oncology, AstraZeneca, Cambridge, UK.
  • Rodriguez PC; Bioscience, Early Oncology, AstraZeneca, Cambridge, UK.
  • Gupta S; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
  • Khleif SN; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Nat Immunol ; 22(1): 53-66, 2021 01.
Article em En | MEDLINE | ID: mdl-33230330
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Imunoterapia Adotiva / Linfócitos T CD8-Positivos / Quinases de Proteína Quinase Ativadas por Mitógeno / Memória Imunológica / Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Imunoterapia Adotiva / Linfócitos T CD8-Positivos / Quinases de Proteína Quinase Ativadas por Mitógeno / Memória Imunológica / Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article