The clinically used serine protease inhibitor nafamostat reduces influenza virus replication and cytokine production in human airway epithelial cells and viral replication in mice.

Yamaya, Mutsuo; Shimotai, Yoshitaka; Ohkawara, Ayako; Bazarragchaa, Enkhbold; Okamatsu, Masatoshi; Sakoda, Yoshihiro; Kida, Hiroshi; Nishimura, Hidekazu

Yamaya, Mutsuo; Shimotai, Yoshitaka; Ohkawara, Ayako; Bazarragchaa, Enkhbold; Okamatsu, Masatoshi; Sakoda, Yoshihiro; Kida, Hiroshi; Nishimura, Hidekazu.

Afiliação

Yamaya M; Virus Research Center, Clinical Research Division, Sendai Medical Center, Sendai, Japan.
Shimotai Y; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ohkawara A; Department of Infectious Diseases, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Bazarragchaa E; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Okamatsu M; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Sakoda Y; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Kida H; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Nishimura H; Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan.

J Med Virol ; 93(6): 3484-3495, 2021 06.

Article em En | MEDLINE | ID: mdl-33247612

Assuntos

Benzamidinas/farmacologia; Benzamidinas/uso terapêutico; Células Epiteliais/efeitos dos fármacos; Guanidinas/farmacologia; Guanidinas/uso terapêutico; Pulmão/efeitos dos fármacos; Inibidores de Serina Proteinase/farmacologia; Inibidores de Serina Proteinase/uso terapêutico; Replicação Viral/efeitos dos fármacos; Animais; Células Cultivadas; Citocinas/análise; Citocinas/imunologia; Células Epiteliais/virologia; Feminino; Humanos; Pulmão/virologia; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Nariz/citologia; Traqueia/citologia

Palavras-chave

antiviral agents; cell cultures; cytokines; influenza virus; protease inhibitor; respiratory tract

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / Benzamidinas / Inibidores de Serina Proteinase / Células Epiteliais / Guanidinas / Pulmão Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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