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Synthesis and Structure-Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases.
Han, Wooseok; Ding, Yu; Chen, Zheng; Langowski, John L; Bellamacina, Cornelia; Rico, Alice; Nishiguchi, Gisele A; Lan, Jiong; Atallah, Gordana; Lindvall, Mika; Lin, Song; Zang, Richard; Feucht, Paul; Zavorotinskaya, Tatiana; Dai, Yumin; Garcia, Pablo; Burger, Matthew T.
Afiliação
  • Han W; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States.
  • Ding Y; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Chen Z; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States.
  • Langowski JL; BeiGene, Ltd., San Mateo, California 94403, United States.
  • Bellamacina C; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States.
  • Rico A; Boston Analytical, Salem, New Hampshire 03079, United States.
  • Nishiguchi GA; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States.
  • Lan J; Kite, a Gilead Company, Emeryville, California 94608, United States.
  • Atallah G; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States.
  • Lindvall M; Crystallographic Consulting, Berkeley, California 94704, United States.
  • Lin S; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States.
  • Zang R; Exelixis, Alameda, California 94502, United States.
  • Feucht P; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States.
  • Zavorotinskaya T; St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
  • Dai Y; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States.
  • Garcia P; Genfleet Therapeutics, Inc., Pudong District, Shanghai 201203, China.
  • Burger MT; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States.
J Med Chem ; 63(23): 14885-14904, 2020 12 10.
Article em En | MEDLINE | ID: mdl-33258605
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicloexanóis / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-pim-1 Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicloexanóis / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-pim-1 Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article