Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas.

Dersh, Devin; Phelan, James D; Gumina, Megan E; Wang, Boya; Arbuckle, Jesse H; Holly, Jaroslav; Kishton, Rigel J; Markowitz, Tovah E; Seedhom, Mina O; Fridlyand, Nathan; Wright, George W; Huang, Da Wei; Ceribelli, Michele; Thomas, Craig J; Lack, Justin B; Restifo, Nicholas P; Kristie, Thomas M; Staudt, Louis M; Yewdell, Jonathan W

Dersh, Devin; Phelan, James D; Gumina, Megan E; Wang, Boya; Arbuckle, Jesse H; Holly, Jaroslav; Kishton, Rigel J; Markowitz, Tovah E; Seedhom, Mina O; Fridlyand, Nathan; Wright, George W; Huang, Da Wei; Ceribelli, Michele; Thomas, Craig J; Lack, Justin B; Restifo, Nicholas P; Kristie, Thomas M; Staudt, Louis M; Yewdell, Jonathan W.

Afiliação

Dersh D; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: devin.dersh@nih.gov.
Phelan JD; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Gumina ME; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Wang B; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Arbuckle JH; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Holly J; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Kishton RJ; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.
Markowitz TE; NIAID Collaborative Bioinformatics Resource, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Seedhom MO; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Fridlyand N; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Wright GW; Biometric Research Branch, Division of Cancer Diagnosis and Treatment, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Huang DW; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ceribelli M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Lack JB; NIAID Collaborative Bioinformatics Resource, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Restifo NP; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.
Kristie TM; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Staudt LM; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Yewdell JW; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: jyewdell@niaid.nih.gov.

Immunity ; 54(1): 116-131.e10, 2021 01 12.

Article em En | MEDLINE | ID: mdl-33271120

Assuntos

Linfócitos B/fisiologia; Biomarcadores Tumorais/genética; Antígenos HLA/genética; Antígenos de Histocompatibilidade Classe II/genética; Antígenos de Histocompatibilidade Classe I/genética; Linfoma Difuso de Grandes Células B/genética; Carcinogênese/genética; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; Diferenciação Celular; Linhagem Celular Tumoral; Linhagem da Célula; Proteína Potenciadora do Homólogo 2 de Zeste/genética; Proteína Potenciadora do Homólogo 2 de Zeste/metabolismo; Regulação Neoplásica da Expressão Gênica; Testes Genéticos; Estudo de Associação Genômica Ampla; Antígenos HLA/metabolismo; Humanos; Vigilância Imunológica; Linfoma Difuso de Grandes Células B/metabolismo; Evasão Tumoral/genética

Palavras-chave

EZH2; HLA class I; MHC class I; MHC class II; SUGT1; antigen presentation; diffuse large B cell lymphoma; immunoevasion; immunotherapy; thymidylate synthase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Antígenos de Histocompatibilidade Classe I / Biomarcadores Tumorais / Antígenos de Histocompatibilidade Classe II / Linfoma Difuso de Grandes Células B / Antígenos HLA Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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