The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2.

Jin, Zhenming; Wang, Haofeng; Duan, Yinkai; Yang, Haitao

Jin, Zhenming; Wang, Haofeng; Duan, Yinkai; Yang, Haitao.

Afiliação

Jin Z; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China; School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China.
Wang H; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China; School of Life Sciences, Tianjin University, Tianjin, China. Electronic address: wanghf@tju.edu.cn.
Duan Y; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Yang H; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China. Electronic address: yanght@shanghaitech.edu.cn.

Biochem Biophys Res Commun ; 538: 63-71, 2021 01 29.

Article em En | MEDLINE | ID: mdl-33288200

Assuntos

Antivirais/química; Proteases 3C de Coronavírus/antagonistas & inibidores; Proteases 3C de Coronavírus/química; Inibidores de Protease de Coronavírus/química; RNA-Polimerase RNA-Dependente de Coronavírus/antagonistas & inibidores; RNA-Polimerase RNA-Dependente de Coronavírus/química; Inibidores Enzimáticos/química; SARS-CoV-2/enzimologia; Antivirais/farmacologia; Inibidores de Protease de Coronavírus/farmacologia; Desenho de Fármacos; Inibidores Enzimáticos/farmacologia; Humanos; Conformação Proteica; SARS-CoV-2/efeitos dos fármacos

Palavras-chave

Inhibitors; Main protease; RNA-dependent RNA polymerase; SARS-CoV-2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores Enzimáticos / Inibidores de Protease de Coronavírus / RNA-Polimerase RNA-Dependente de Coronavírus / Proteases 3C de Coronavírus / SARS-CoV-2 Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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