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Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates.
Feng, Bo; Pemberton, Rachel; Dworakowski, Wojciech; Ye, Zhengqi; Zetterberg, Craig; Wang, Guanyu; Morikawa, Yoshio; Kumar, Sanjeev.
Afiliação
  • Feng B; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., R.P., W.D., Z.Y., C.Z., G.W., S.K.) and PhoenixBio USA Corporation, New York City, New York (Y.M.) Bo_Feng@vrtx.com.
  • Pemberton R; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., R.P., W.D., Z.Y., C.Z., G.W., S.K.) and PhoenixBio USA Corporation, New York City, New York (Y.M.).
  • Dworakowski W; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., R.P., W.D., Z.Y., C.Z., G.W., S.K.) and PhoenixBio USA Corporation, New York City, New York (Y.M.).
  • Ye Z; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., R.P., W.D., Z.Y., C.Z., G.W., S.K.) and PhoenixBio USA Corporation, New York City, New York (Y.M.).
  • Zetterberg C; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., R.P., W.D., Z.Y., C.Z., G.W., S.K.) and PhoenixBio USA Corporation, New York City, New York (Y.M.).
  • Wang G; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., R.P., W.D., Z.Y., C.Z., G.W., S.K.) and PhoenixBio USA Corporation, New York City, New York (Y.M.).
  • Morikawa Y; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., R.P., W.D., Z.Y., C.Z., G.W., S.K.) and PhoenixBio USA Corporation, New York City, New York (Y.M.).
  • Kumar S; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, Boston, Massachusetts (B.F., R.P., W.D., Z.Y., C.Z., G.W., S.K.) and PhoenixBio USA Corporation, New York City, New York (Y.M.).
Drug Metab Dispos ; 49(3): 254-264, 2021 03.
Article em En | MEDLINE | ID: mdl-33376106
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quimera / Transportadores de Ânions Orgânicos / Fígado Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quimera / Transportadores de Ânions Orgânicos / Fígado Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article