Danggui Sini decoction protects against oxaliplatin-induced peripheral neuropathy in rats.
J Integr Neurosci
; 19(4): 663-671, 2020 Dec 30.
Article
em En
| MEDLINE
| ID: mdl-33378840
ABSTRACT
The effects of Danggui Sini decoction on peripheral neuropathy in oxaliplatin-induced peripheral is established. The results indicated that Danggui Sini decoction treatment significantly reduced the current amplitude of dorsal root ganglia cells undergoing agonists stimuli compared to the model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment significantly inhibited the inflammatory response of dorsal root ganglia cells compared to the model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment significantly enhanced the amounts of Nissl bodies in dorsal root ganglia cells compared to the Model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment improved ultra-microstructures of dorsal root ganglia cells. In conclusion, Danggui Sini decoction protected against neurotoxicity of oxaliplatin-induced peripheral neuropathy in rats by suppressing inflammatory lesions, improving ultra-microstructures, and enhancing amounts of Nissl bodies.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
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Doenças do Sistema Nervoso Periférico
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Síndromes Neurotóxicas
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Oxaliplatina
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Gânglios Espinais
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Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article