Deletion of P21-activated kinase-1 induces age-dependent increased visceral adiposity and cardiac dysfunction in female mice.

Batra, Ashley; Warren, Chad M; Ke, Yunbo; McCann, Maximilian; Halas, Monika; Capote, Andrielle E; Liew, Chong Wee; Solaro, R John; Rosas, Paola C

Batra, Ashley; Warren, Chad M; Ke, Yunbo; McCann, Maximilian; Halas, Monika; Capote, Andrielle E; Liew, Chong Wee; Solaro, R John; Rosas, Paola C.

Afiliação

Batra A; Department of Physiology & Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
Warren CM; Department of Physiology & Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
Ke Y; Department of Anesthesiology, School of Medicine, University of Maryland, Baltimore, MD, USA.
McCann M; Department of Physiology & Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
Halas M; Department of Physiology & Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
Capote AE; Department of Physiology & Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
Liew CW; Department of Physiology & Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
Solaro RJ; Department of Physiology & Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
Rosas PC; Department of Physiology & Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA. prosas@uic.edu.

Mol Cell Biochem ; 476(3): 1337-1349, 2021 Mar.

Article em En | MEDLINE | ID: mdl-33389497

Assuntos

Adiposidade; Gordura Intra-Abdominal/metabolismo; Disfunção Ventricular/metabolismo; Quinases Ativadas por p21/genética; Quinases Ativadas por p21/metabolismo; Envelhecimento; Animais; Diástole; Ecocardiografia; Feminino; Coração/fisiologia; Insuficiência Cardíaca/metabolismo; Masculino; Camundongos; Camundongos Knockout; Miocárdio/metabolismo; Fosforilação; Volume Sistólico; Proteína cdc42 de Ligação ao GTP/metabolismo

Palavras-chave

Adipose tissue; Aging; Diastolic dysfunction; Females; Heart failure with preserved ejection fraction; Obesity; P21-activated kinase-1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Disfunção Ventricular / Gordura Intra-Abdominal / Adiposidade / Quinases Ativadas por p21 Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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