ET<sub>A</sub>R silencing ameliorated neurovascular injury after SAH in rats through ERK/KLF4-mediated phenotypic transformation of smooth muscle cells.

Zhang, Zhaosi; Chen, Hong; Liu, Liu; Zhao, Guosheng; He, Junchi; Liu, Han; Zhou, Chao; Liu, Xiaoshuang; Sun, Xiaochuan; Guo, Zongduo

ET_AR silencing ameliorated neurovascular injury after SAH in rats through ERK/KLF4-mediated phenotypic transformation of smooth muscle cells.

Zhang, Zhaosi; Chen, Hong; Liu, Liu; Zhao, Guosheng; He, Junchi; Liu, Han; Zhou, Chao; Liu, Xiaoshuang; Sun, Xiaochuan; Guo, Zongduo.

Afiliação

Zhang Z; Department of Cerebrovascular Diseases, Affiliated Hospital of Zunyi Medical University, Guizhou, China.
Chen H; Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liu L; Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhao G; Department of Orthopedic Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
He J; Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liu H; Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhou C; Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liu X; Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Sun X; Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: sunxch1445@qq.com.
Guo Z; Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: stonegzd@163.com.

Exp Neurol ; 337: 113596, 2021 03.

Article em En | MEDLINE | ID: mdl-33417892

Assuntos

Fatores de Transcrição Kruppel-Like/genética; Sistema de Sinalização das MAP Quinases/genética; Miócitos de Músculo Liso/patologia; Receptores de Endotelina/genética; Hemorragia Subaracnóidea/genética; Animais; Animais Geneticamente Modificados; Movimento Celular; Circulação Cerebrovascular; Células Endoteliais/metabolismo; Endotelina-1/genética; Técnicas de Silenciamento de Genes; Humanos; Fator 4 Semelhante a Kruppel; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Fenótipo; RNA Interferente Pequeno/genética; Ratos; Ratos Sprague-Dawley; Receptor de Endotelina A; Hemorragia Subaracnóidea/patologia

Palavras-chave

ET(A)R; ET-1; Endothelial cells; Erk1/2; KLF4; Smooth muscle cells; Subarachnoid haemorrhage

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemorragia Subaracnóidea / Receptores de Endotelina / Sistema de Sinalização das MAP Quinases / Miócitos de Músculo Liso / Fatores de Transcrição Kruppel-Like Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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