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Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.
Zhan, Wenhu; Zhang, Hao; Ginn, John; Leung, Annie; Liu, Yi J; Michino, Mayako; Toita, Akinori; Okamoto, Rei; Wong, Tzu-Tshin; Imaeda, Toshihiro; Hara, Ryoma; Yukawa, Takafumi; Chelebieva, Sevil; Tumwebaze, Patrick K; Lafuente-Monasterio, Maria Jose; Martinez-Martinez, Maria Santos; Vendome, Jeremie; Beuming, Thijs; Sato, Kenjiro; Aso, Kazuyoshi; Rosenthal, Philip J; Cooper, Roland A; Meinke, Peter T; Nathan, Carl F; Kirkman, Laura A; Lin, Gang.
Afiliação
  • Zhan W; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
  • Zhang H; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
  • Ginn J; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA.
  • Leung A; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
  • Liu YJ; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
  • Michino M; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA.
  • Toita A; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA.
  • Okamoto R; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA.
  • Wong TT; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA.
  • Imaeda T; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA.
  • Hara R; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA.
  • Yukawa T; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA.
  • Chelebieva S; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, 94901, USA.
  • Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Lafuente-Monasterio MJ; Diseases of the Developing World (DDW), Tres Cantos Medicine Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain.
  • Martinez-Martinez MS; Diseases of the Developing World (DDW), Tres Cantos Medicine Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain.
  • Vendome J; Schrödinger, Inc., New York, NY, 10036, USA.
  • Beuming T; Schrödinger, Inc., New York, NY, 10036, USA.
  • Sato K; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA.
  • Aso K; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA.
  • Rosenthal PJ; Department of Medicine, University of California, San Francisco, CA, 94143, USA.
  • Cooper RA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, 94901, USA.
  • Meinke PT; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA.
  • Nathan CF; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
  • Kirkman LA; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
  • Lin G; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Angew Chem Int Ed Engl ; 60(17): 9279-9283, 2021 04 19.
Article em En | MEDLINE | ID: mdl-33433953
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Malária Falciparum / Complexo de Endopeptidases do Proteassoma / Inibidores de Proteassoma / Desenvolvimento de Medicamentos / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Malária Falciparum / Complexo de Endopeptidases do Proteassoma / Inibidores de Proteassoma / Desenvolvimento de Medicamentos / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article